Perfusion measurements by dynamic susceptibility MRI
نویسنده
چکیده
List of Papers This thesis is based on the following papers, which are referred to in the text by their Roman numerals. Abbreviations ADC Apparent diffusion coefficient AIF Arterial input function ASL Arterial spin labeling CBF Cerebral blood flow CBV Cerebral blood volume CPB Cardio pulmonary bypass DSC-MRI Dynamic susceptibility contrast MRI MRI Magnetic resonance imaging MRS Magnetic resonance spectroscopy MTT Mean transit time R 1 Longitudinal relaxation rate (s-1) r 1 Dipolar T 1 relaxivity of a contrast agent (s-1 mM-1) R 2 Transversal relaxation rate (s-1) r 2 Dipolar T 2 relaxivity of a contrast agent (s-1 mM-1) R 2 * Effective transversal relaxation rate (s-1) SACP Selective antegrade cerebral perfusion SVD Singular value decomposition T/R Transmit receive T 1 Longitudinal relaxation time (ms) T 2 Transversal relaxation time (ms) T 2 * Effective transversal relaxation time (ms) TE Echo time (ms) TR Repetition time (ms) TTP Time to peak USPIO Ultrasmall particles of iron-oxide 10 Introduction
منابع مشابه
An Efficient Framework for Accurate Arterial Input Selection in DSC-MRI of Glioma Brain Tumors
Introduction: Automatic arterial input function (AIF) selection has an essential role in quantification of cerebral perfusion parameters. The purpose of this study is to develop an optimal automatic method for AIF determination in dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) of glioma brain tumors by using a new preprocessing method.Material and Methods: For this study, ...
متن کاملDynamic contrast-enhanced susceptibility-weighted perfusion imaging of intracranial tumors: a study using a 3T MR scanner.
PURPOSE To determine whether there are statistically significant differences in cerebral blood volume (CBV) and cerebral blood flow (CBF) of brain tumors of different histopathologic types including primary and secondary benign and malignant lesions. To determine whether these measurements relate to tumor grade. MATERIALS AND METHODS Forty-five patients with brain tumors, age 2 to 79 years, u...
متن کاملDynamic susceptibility contrast MRI with localized arterial input functions.
Compared to gold-standard measurements of cerebral perfusion with positron emission tomography using H(2)[(15)O] tracers, measurements with dynamic susceptibility contrast MR are more accessible, less expensive, and less invasive. However, existing methods for analyzing and interpreting data from dynamic susceptibility contrast MR have characteristic disadvantages that include sensitivity to in...
متن کاملOn the theoretical basis of perfusion measurements by dynamic susceptibility contrast MRI.
A quantitative analysis was undertaken to calibrate the perfusion quantification technique based on tracking the first pass of a bolus of a blood pool contrast agent. A complete simulation of the bolus passage, of the associated changes in the T2 and T2* signals, and of the data processing was performed using the tracer dilution theory, an analytical theory of the MR signal from living tissues ...
متن کاملPerfusion MRI (dynamic susceptibility contrast imaging) with different measurement approaches for the evaluation of blood flow and blood volume in human gliomas.
BACKGROUND Perfusion magnetic resonance imaging (MRI) is increasingly used in the evaluation of brain tumors. Relative cerebral blood volume (rCBV) is usually obtained by dynamic susceptibility contrast (DSC) MRI using normal appearing white matter as reference region. The emerging perfusion technique arterial spin labelling (ASL) presently provides measurement only of cerebral blood flow (CBF)...
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